Milan Hejduk scored the lone shootout goal as Colorado pulled out a 4-3 win at Florida.
The Avalanche grabbed a 3-2 lead in the third period on Andrew Brunette's second goal of the game. Olli Jokinen scored just over 3 minutes later to extend the game, but he failed to score in the shootout.
Marek Svatos also scored and Jose Theodore turned back 30 shots as the Avs dealt the Panthers their sixth consecutive home loss.
Colorado has eight straight road wins versus the Panthers.
David Booth and Jay Bouemeester tallied for Florida.