Broncos leading rusher Willis McGahee is expected to have surgery later this week for a broken finger on his right hand and will not play against Detroit on Sunday.
McGahee didn't return after hurting the finger in the third quarter of an 18-15 overtime win over the Dolphins. He finished with 76 yards on 18 attempts.
The ninth-year pro is fifth in the AFC in rushing with 460 yards.
With McGahee sidelined, the Broncos will rely on Knowshon Moreno and Lance Ball to pick up the slack against the Lions.
Defensive ends Robert Ayers (knee) and Elvis Dumervil (ankle) also were banged up against the Dolphins. Coach John Fox said Monday that more information on their status would be available later in the week.