The southwest mountains are expected to receive as much as two feet by Monday. The Denver area and even the parched northeastern plains are expecting heavy snow by Tuesday.
The much needed snow would help the snowpack, which is above last year but only about 85% of average.
Melting snow contributes about 80% of the water in rivers, streams, lakes and reservoirs, which comprise much of the state's water supply. Eight major Colorado river systems also provide water to 10 western states.
Officials also hope more snow will help delay the start of the wildfire season.