Interior Secretary Ken Salazar will leave the Obama administration in March.
Salazar has run the Interior Department throughout President Barack Obama's first term. Before joining the Cabinet, he served as a senator from Colorado.
Salazar is the latest Cabinet secretary to leave the administration as Obama heads into his second term. Secretary of State Hillary Rodham Clinton, Pentagon chief Leon Panetta, Treasury Secretary Timothy Geithner and Labor Secretary Hilda Solis are also leaving.