No one knows for sure just how many people Patrick Sawyer came into contact with the day he boarded a flight in Liberia, had a stopover in Ghana, changed planes in Togo, and then arrived in Nigeria, where authorities say he died days later from Ebola, one of the deadliest diseases known to man.
Now health workers are scrambling to trace those who may have been exposed to Sawyer across West Africa, including flight attendants and fellow passengers.
Health experts say it is unlikely he could have infected others with the virus that can cause victims to bleed from the eyes, mouth and ears. Still, unsettling questions remain: How could a man whose sister recently died from Ebola manage to board a plane leaving the country? And worse: Could Ebola become the latest disease to be spread by international air travel?
The CDC has issued a health alert for American doctors, but even if the disease comes to the U.S., there is little fear of it spreading, Dr. Jon LaPook told "CBS This Morning." The disease itself has up to a three-week incubation period, which is why the CDC issued the alert. However, most U.S. health officials believe that keen awareness of symptoms of the disease and speedy isolation of potential victims is enough to contain it here.
Sawyer's death on Friday has led to tighter screening of airline passengers in West Africa, where an unprecedented outbreak that emerged in March has killed more than 670 people in Guinea, Sierra Leone and Liberia.
The airline Sawyer took, ASKY, announced Tuesday it was temporarily halting flights not only to Monrovia but also to Freetown, Sierra Leone. Flights will continue to the capital of the third major country where people have died - Guinea - though passengers departing from there will be "screened for signs of the virus."
Passengers at the airline's hub in Lome, Togo, also will be screened by medical teams, it said.
"ASKY is determined to keep its passengers and staff safe during this unsettling time," the statement said.
But some health authorities expressed little confidence in such precautions.
"The best thing would be if people did not travel when they were sick, but the problem is people won't say when they're sick. They will lie in order to travel, so it is doubtful travel recommendations would have a big impact," said Dr. David Heymann, professor of infectious diseases at the London School of Hygiene and Tropical Medicine.
"The important thing is for countries to be prepared when they get patients infected with Ebola, that they are isolated, family members are told what to do and health workers take the right steps."
The World Health Organization is awaiting laboratory confirmation after Nigerian health authorities said Sawyer tested positive for Ebola, WHO spokesman Gregory Hartl said. The WHO has not recommended any travel restrictions since the outbreak came to light.
"We would have to consider any travel recommendations very carefully, but the best way to stop this outbreak is to put the necessary measures in place at the source of infection," Hartl said. Closing borders "might help, but it won't be exhaustive or foolproof."
The risk of travelers contracting Ebola is considered low because it requires direct contact with bodily fluids or secretions such as urine, blood, sweat or saliva, experts say. Ebola can't be spread like flu through casual contact or breathing in the same air.
Patients are contagious only once the disease has progressed to the point they show symptoms, according to the WHO. And the most vulnerable are health care workers and relatives who come in much closer contact with the sick.
Still, witnesses say Sawyer, a 40-year-old Liberian Finance Ministry employee en route to a conference in Nigeria, was vomiting and had diarrhea aboard at least one of his flights with some 50 other passengers aboard. Ebola can be contracted from traces of feces or vomit, experts say.
Sawyer was immediately quarantined upon arrival in Lagos - a city of 21 million people - and Nigerian authorities say his fellow travelers were advised of Ebola's symptoms and then were allowed to leave. The incubation period can be as long as 21 days, meaning anyone infected may not fall ill for several weeks.
"If it gets into a big city, that's everybody's worse nightmare," said Dr. Tim Geisbert, a professor of microbiology and immunology at University of Texas Medical Branch, in an interview with CBS News. "It gets harder to control then. How do you quarantine a big city?"
This particular Ebola outbreak isn't just scaring health officials due to its spread, but also because of the rate at which healthcare workers themselves are falling ill.
Health officials tracking the disease rely on "contact tracing" - locating anyone who may have been exposed, and then anyone who may have come into contact with that person. That may prove impossible, given that other passengers journeyed on to dozens of other cities.
Patrick Sawyer had planned to visit his family in Minnesota next month to attend two of his three daughters' birthdays, his wife, Decontee Sawyer, told KSTP-TV in Minnesota.
"It's a global problem because Patrick could have easily come home with Ebola, easy," she said. The Associated Press left phone and email messages for her Monday.
International travel has made the spread of disease via airplanes almost routine. Outbreaks of measles, polio and cholera have been traced back to countries thousands of miles away. Even Ebola previously traveled the globe this way: During an outbreak in Ivory Coast in the 1990s, the virus infected a veterinarian who traveled to Switzerland, where the disease was snuffed out upon arrival and she ultimately survived, experts say.
Two American aid workers in Liberia have tested positive for the virus and are being treated there. U.S. health officials said Monday that the risk of the deadly germ spreading to the United States is remote.
The mere prospect of Ebola in Africa's most populous nation has Nigerians on edge.
In Nigeria's capital, Abuja, Alex Akinwale, a 35-year-old entrepreneur, said he is particularly concerned about taking the bus, which is the only affordable way to travel.
"It's actually making me very nervous. If I had my own car, I would be safer," he said. "The doctors are on strike, and that means they are not prepared for it. For now I'm trying to be very careful."
It's an unprecedented public health scenario: Since 1976, when the virus was first discovered, Ebola outbreaks were limited to remote corners of Congo and Uganda, far from urban centers, and stayed within the borders of a single country. This time, cases first emerged in Guinea, and before long hundreds of others were stricken in Liberia and Sierra Leone.
Those are some of the poorest countries in the world, with few doctors and nurses to treat sick patients let alone determine who is well enough to travel. In Sawyer's case, it appears nothing was done to question him until he fell sick on his second flight with Asky Airlines. An airline spokesman would not comment on what precautions were being taken in the aftermath of Sawyer's journey.
Liberian Assistant Health Minister Tolbert Nyenswah told The Associated Press last week that there had been no screening at Liberia's Monrovia airport. That changed quickly over the weekend, when President Ellen Johnson Sirleaf said a new policy on inspecting and testing all outgoing and incoming passengers will be strictly observed. She also announced that some borders were being closed and communities with large numbers of Ebola cases would be quarantined.
International travelers departing from the capitals of Sierra Leone and Guinea are also being checked for signs of fever, airport officials said. Buckets of chlorine are also on hand at Sierra Leone's airport in Freetown for disinfection, authorities said.
Still, detecting Ebola in departing passengers might be tricky, since its initial symptoms are similar to many other diseases, including malaria and typhoid fever.
"It will be very difficult now to contain this outbreak because it's spread," Heymann said. "The chance to stop it quickly was months ago before it crossed borders ... but this can still be stopped if there is good hospital infection control, contact tracing and collaboration between countries."
Nigerian authorities so far have identified 59 people who came into contact with Sawyer and have tested 20, said Lagos State Health Commissioner Jide Idris. Among them were officials from ECOWAS, a West African governing body, airline employees, health workers and the Nigerian ambassador to Liberia, he said. He said there have been no new cases of the disease.