Transportation officials have opened the eastbound lanes of Interstate 70 over Vail Pass after an accident involving as many as 75 vehicles shutdown the highway.
The state Transportation Department says traffic will be allowed to pass in increments, and warned delays would be likely.
Authorities say at least one person died and several others were injured in the pile-up.
A Colorado State Patrol trooper says between 60 and 75 vehicles are involved in the wreck. The accident happened during snowy weather and forced the closure of the interstate.
Vail Valley Medical Center spokesman Don Bishop says at least 16 people with broken bones, bruises, and scrapes were transported to the hospital, about 15 miles west of the scene. Except for one patient who was to undergo surgery, Bishop says all were in fair condition.
Six patients were transported to St. Anthony's Summit Medical Center near Breckenridge, about 20 miles away. Two women there were in critical condition, anther woman and a boy were in serious condition. The other two patients were treated and discharged.
Trooper Gilbert Sullivan says a semitrailer jackknifed and caused the original crash.