The Broncos are out of the playoffs.
Denver flirted with a comeback Sunday with touchdowns on its first three possessions of the second half, but a 35-point first half carried Indianapolis to a 49-to-24 win over the Broncos.
Peyton Manning completed 27 of 33 passes for 457 yards, including a record 360 yards in the first half.
Reggie Wayne caught ten passes for 221 yards and two touchdowns, and Dallas Clark caught six for 112 yards. Manning threw for four touchdowns and scored on a one-yard sneak.
Edgerrin James added 63 rushing yards.
Denver's Jake Plummer finished 24 of 34 for 284 yards with two touchdowns and one interception.
The Colts face New England next weekend in the second round of the playoffs.